The Agency for Healthcare Research and Quality has issued a toolkit to help hospitals reduce C. difficile infections by reducing inappropriate use of antibiotics, which may contribute to infections. Boston University School of Public Health collaborated with Montefiore Medical Center and the Greater New York Hospital Association/United Hospital Fund to develop the toolkit for AHRQ and the Centers for Disease Control and Prevention with help from 10 New York hospitals.
The toolkit incorporates lessons learned from hospitals that served as intervention sites.

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